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This has resulted in delayed elimination of the drug, but long-term renal sequelae have not been described.
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An increased incidence of thromboembolic events has been reported in women receiving cyclophosphamide, methotrexate, and fluorouracil as treatment for breast cancer.
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Risk of dose-related toxicities, including myelosuppression, nausea, vomiting, and cumulative, severe renal toxicity.
Because it affects most on the abdominal area, the symptoms are also related to the affected system and may last for some time or even more than a year.
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Based on the mechanism of action, cyclophosphamide may cause fetal harm if administered during pregnancy.
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CR in the absence of total platelet recovery (CRp)) and remissions were also observed in patients who were refractory to standard salvage treatments.
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Although not overly superior, the weight of evidence favors CYTBI over BUCY as a first choice-conditioning regimen in patients with leukemia.
However, some diseases, such as sarcoidosis and lymphangioleiomyomatosis, have only decreased breath sounds without adventitious sounds despite markedly abnormal chest radiographs.
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The authors of this study concluded that this treatment protocol was fairly well tolerated and it was effective in delaying tumor recurrence in dogs with incompletely resected soft tissue sarcomas.
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Fourth, haploidentical transplants were performed at 19 transplant centers, whereas unrelated donor transplants were performed at several more centers representing clinical practice across small-, mid-, and large-sized transplant centers.
Azathioprine was selected for use in this study because it was already widely used for the maintenance of remission in patients with renal vasculitis.
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The median age for the enrolled patients was 64 years (range; 44-82 years), and 19 (54%) were male.
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The antioxidant effects of vitamin E significantly decreased the number of TUNEL-positive cells and the ALT and MDA levels, and normalized the liver histopathology.
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Cyclophosphamide and glucocorticoids have been the standard therapy for remission induction for nearly four decades.
Hair loss occurs about 3-4 weeks after the first dose.
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Patients with 5 % BM blasts could receive a second cycle of induction and, if not able to achieve a response, were discontinued from further study therapy.
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Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity.
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Patients with contralateral breast cancer, second primary malignancy, or death from causes other than breast cancer were censored at the time of the last visit prior to these events.
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Ongoing phase 3 studies by the Gynecologic Oncology Group and the Southwest Oncology Group will further define the role of intraperitoneal cisplatin (and intravenous paclitaxel) in the treatment of stage III ovarian cancer that has been optimally resected.
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Among patients in the control group, we expected a remission rate of 80% and a sustained-remission rate of 65% because of early relapses.
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Infection, active vasculitis and acute kidney injury appear to be the leading causes of mortality during this time.
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Belinostat in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results of the Pivotal Phase II BELIEF (CLN-19) Study.
Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen.
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Transplant conditioning regimens included TBI-containing (20%), busulfan and cyclophosphamide (38%), melphalan and thiotepa (27%), and busulfan and fludarabine (15%).
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