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The beneficial effects of thyroxine substitution therapy on Lp(a) levels in SH subjects are also debated.

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Sporadic primary hyperparathyroidism (PHPT) is a disease characterized by persistent elevated levels of serum calcium attributable to an autonomous production of PTH from a diseased parathyroid gland.

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These include renal or liver disease, malignancy, primary hyperparathyroidism, vitamin D deficiency, malabsorption, malnutrition, myeloma, and hyperthyroidism.

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In the treatment of well-differentiated (papillary and follicular) thyroid cancer, levothyroxine is used as an adjunct to surgery and radioiodine therapy.

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Very definitely a case where one size will not fit all, though at 10x the generally proper T3 dose very few will do well in the long term, as the trials have verified.

In most countries, the best strategy to control iodine deficiency in populations is carefully monitored universal salt iodization, one of the most cost-effective ways to contribute to economic and social development.

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Consequently most physicians are at a loss to treat the latter as well, and often resort to quinine or drugs to stop this symptom artificially.

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Failing to fulfill the Duty to Warn, for example, by notifying third parties or authorities when severely hypothyroid patients are driving and are known threats to public safety or even child safety (if driving children), is a violation of Non-Maleficence ().

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In another report, only 44% of T 4-treated patients with an elevated TSH had dosages increased by their physicians who were aware of the TSH findings; even more astounding was the fact that only 11% of the patients with low TSH levels on l-thyroxine replacement had their doses decreased ()!

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The extent to which central hypothyroidism, versus reduced D1 activity, and increased D3-mediated clearance in peripheral tissues cause NTIS remains to be determined, but one study of critically ill patients in which central hypothyroidism was corrected via TRH infusion suggests that the central effect predominates ().

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