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Discontinuation of the drug for lack of efficacy was highest among patients in on Seroquel (28%) and lowest for those on Zyprexa (15%).
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The results indicate that working memory improves independently from negative symptoms reduction.
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Whereas aberrant salience was calculated using the absolute differences between equally reinforced conditioned stimuli, adaptive salience was calculated for reinforced compared to non-reinforced conditioned stimuli.
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Results: While GHR individuals consistently have findings that are more deviant than low genetic risk controls (GLR), they are not as deviant as patients with chronic schizophrenia.
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The purpose of this study is to determine if a children's food preferences following treatment for pediatric food refusal continue to impact mealtimes.
Results: By means of a paired t test, we found in whole HR sample a significant average full-scale IQ decline of -2.
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Results: Experiments are currently underway and we hypothesize that we will identify altered expression of some of the GABAA and GABAB receptor subunits in BA9 of subjects with schizophrenia and bipolar disorder.
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Change in performance on a verbal learning task (a 6 item “shopping list” visually presented with 30 seconds of encoding time and immediate free recall, with different words used in the second presentation) initially presented in the first session of the cognitive program, and again in the 6th session of the program, was compared in the two groups of participants.
Therefore, we investigated structural correlates of impaired gesture performance in schizophrenia.
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We showed that, for both psychological treatments, improving TA improves symptomatic outcome.
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Methods: Brain magnetic resonance images were acquired in 44 SCHZ, 39 SIP, and 83 Non-psychotic substance users (NPS) matched for age, socio-economic status and patterns of substance use.
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Depressive episodes pose a particular challenge because many antidepressant drugs pose a risk for triggering mania.
Symptoms often appear within a few weeks of beginning the antipsychotic or increasing the dosage, but can also arise after long-term stable use.
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Methods: We developed a social cognitive intervention that limits cognitive load by relying on methods that have previously been successfully used in neurocognitive remediation: errorless learning, hierarchical training, massed drill and practice, and verbal mediation, to name a few.
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Treatment with sertraline, with or without group cognitive behavior therapy, reduced the functional impairment of depression.
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Similar but less extensive GMV changes were seen in SZ and SAD relatives; in contrast, BDP relatives had normal GMV.
Symptoms may appear by age 2, but the average age of onset is between 3 and 4 years.
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We have recently found that regular cannabis use is associated with reduced striatal dopamine synthesis capacity (DSC), contrary to a leading interpretation of the dopamine hypothesis which postulates that elevated striatal DSC causes psychosis by creating “Aberrant Salience” (AS).
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Lithium has been used for more than 60 years to treat bipolar disorder.
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Methods: This project is a 9-month, randomized controlled trial comparing medication adherence, medication self-efficacy and psychiatric symptoms in community dwelling persons with SSDs.
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Efficacy and tolerability of pharmacotherapy for smoking cessation in adults with serious mental illness: a systematic review and network meta-analysis.
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Conclusion: Genetic, and to a lesser extent biochemical findings, are consistent with neuroimaging and neuropathological evidence linking glia-related white matter inflammation to the pathophysiology of schizophrenia.
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